VM8054 Veterinary Histology

Esophageal-Stomach Junction

Author: Dr. Thomas Caceci


The image to the left is of the esophageal-stomach junction (E-S Jct). On the right side you see the stratified squamous epithelium of the esophagus (E) which terminates abruptly at the point of entry into the stomach (S). The lining of the stomach is a simple columnar type without goblet cells.

There is no particularly thickened region of the tunica muscularis at this location, however. Although you will hear the term "esophageal sphincter" there isn't much in the way of a true anatomical sphincter at the entrance to the stomach, as there is at the outlet. The "esophageal sphincter" is physiological: intra-esophageal pressures are generally higher than those of the stomach, and hence reflux of the stomach contents is prevented.

Occasionally there is a drop in intra-esophageal pressure and reflux occurs. It's perceived symptomatically as "heartburn" in humans. If it persists the erosive effect of the acid stomach contents can cause ulceration of the lower esophagus.

Dog stomach; H&E stain, paraffin section, 20x
In most species the epithelial transition from esophagus to stomach is right about at the point where the anatomic esophagus and the anatomic stomach meet. But in others (such as the horse and rat) it occurs actually inside the anatomic stomach. Thus the gross anatomist will speak of the "non-glandular" and "glandular" regions of the stomach. In suchsituations the point of change is easily visible, and the gross anatomist's term for it is the margo plicatus.

Here is an example of the margo plicatus from a rat. This particular transition occurs very deep and the region of the stomach next to the "esophageal" epithelium actually contains fundic glands!

 

 

Rat stomach; H&E stain, paraffin section, 100x

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